23 October 2023 - New paper from our group published in Nature Communications!
This work was done during Marie's postdoc at Columbia University in New York in Christoph Kellendonk's lab https://www.kellendonklab.org/ and was finished up as Marie joined ETH.
In short: the basal ganglia Go and NoGo pathways are classically described as anatomically segregated and functionally opposing. They are made of striatal D1 and D2 neurons and project to the midbrain and globus pallidus, respectively. Here we describe a non-canonical Go pathway made of axon collaterals from D1 neurons that project to the globus pallidus (rather than the midbrain) and promote motor action.
